Thrombotic thrombocytopenic purport (TTP ) is a thrombotic disorder and is, and in this thrombotic disorder, there is microthrombi. Formation. There are a large number of microthrombi that are generated in the small and large blood vessels.
These microthrombi consume a large number of platelets that eventually give rise to thrombocytopenia in the peripheral blood, so the patient may have symptoms due to decreased platelet count and the patient may have all those classical clinical manifestations. The deficiency of the cleaving enzyme ADAMTS13 is the pathognomic event that gives rise to all of this process.
The classic pentad of symptoms include
-Fever
-Thrombocytopenia
Renal failure –
-Neurological symptoms,
Hemolytic Anemia with schistocytes
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